Surfactant as salvage therapy in life threatening primary graft dysfunction in lung transplantation
نویسندگان
چکیده
منابع مشابه
Surfactant as salvage therapy in life threatening primary graft dysfunction in lung transplantation.
OBJECTIVE Impaired surfactant activity may contribute to primary graft dysfunction after lung transplantation. We assessed the role of surfactant treatment in lung transplant recipients with severe life threatening primary lung graft dysfunction. PATIENTS AND METHODS Five patients after lung transplantation: 4 after single-lung transplantation, for emphysema (n=3) or idiopathic pulmonary fibr...
متن کاملPrimary Graft Dysfunction After Lung Transplantation.
Primary graft dysfunction is a form of acute injury after lung transplantation that is associated with significant short- and long-term morbidity and mortality. Multiple mechanisms contribute to the pathogenesis of primary graft dysfunction, including ischemia reperfusion injury, epithelial cell death, endothelial cell dysfunction, innate immune activation, oxidative stress, and release of infl...
متن کاملLong Term Impact of Primary Graft Dysfunction after Lung Transplantation
According to the International Society for Heart and Lung Transplantation (ISHLT) Registry, graft failure accounted for 24.7% of deaths within 30 days of transplantation among adult lung recipients between 1992 and 2012 [1]. Although important details distinguishing different causes of early graft failure may be missing from the Registry data, it is likely that primary graft dysfunction (PGD) i...
متن کاملLung transplantation: Mycobacterium abscessus as a cause of graft dysfunction
in patients with end-stage lung diseases where other effective treatments are lacking [1]. However, the procedure is not without risks and side-effects. One of the most important causes of morbidity and mortality in these patients is infection [1, 2]. Recently, there has been an increase in the incidence of emerging infections, with the majority of mycobacterial infections due to Mycobacterium ...
متن کاملAprotinin in lung transplantation is associated with an increased incidence of primary graft dysfunction.
OBJECTIVE Aprotinin has been widely used to reduce bleeding and transfusion requirements in cardiac surgery and in lung transplantation. A recent study found a significant reduction in severe (grade III) primary graft dysfunction (PGD) in lung transplantation where aprotinin had been used. However, recently, concerns regarding the safety of aprotinin have been raised, and the future use of apro...
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ژورنال
عنوان ژورنال: European Journal of Cardio-Thoracic Surgery
سال: 2009
ISSN: 1010-7940
DOI: 10.1016/j.ejcts.2008.09.039